I remember back when The X-Files was on, I was a huge M/S shipper and my friend wasn't as much of one. She said that if they got together, the show would be over/it would ruin what they had going. I said that I agreed. I loved reading about them, but if they ever did get together on the show, it would have to be at the end.

More often than not, writers tend to screw up romantic relationships. Or the relationships get old within the plots of the show so they have to 'shake things up' to make it interesting again. For the most part, I trust the fans to do their favorite pairings justice.